Living in a world where a small amount of sperm can result in pregnancy by IVF(In Vitro Fertilisation), selecting healthy sperm is essential. Sperm DNA Fragmentation tends to be higher in infertile men. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) and the alkaline comet test are SDF tests that directly measure DNA damage and have shown accurate results. 

If the result shows a high level of SDF, then they are advised to decrease SDF through lifestyle changes, antioxidant treatments, and by treating the underlying conditions of patients. 

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